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Rare cases of muscle problems and liver problems have been associated with the use of atorvastatin and other similar medicines. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or flulike symptoms or yellowing of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. These may be early symptoms of muscle or liver problems. Do not take atorvastatin without first talking to your doctor if you have liver disease. Alcohol and atorvastatin can both be damaging to the liver. Alcohol should be used only in moderation. Discuss the use of alcohol with your doctor so that the potential for liver problems can be determined. Do not take atorvastatin if you are pregnant, could become pregnant during treatment, or if you are breast-feeding a baby. What is atorvastatin? Atorvastatin is an HMG CoA reductase inhibitor. Atorvastatin blocks the production of cholesterol (a type of fat) in the body. Atorvastatin is used to reduce the amounts of LDL (bad) cholesterol, total cholesterol, triglycerides (another type of fat), and apolipoprotein B (a protein needed to make cholesterol) in your blood. Atorvastatin is also used to increase the level of HDL (good) cholesterol in your blood. These actions are important in reducing the risk of hardening of the arteries, which can lead to heart attacks, stroke, and peripheral vascular disease. Atorvastatin may also be used for purposes other than those listed in this medication guide. How should I take atorvastatin? Take atorvastatin exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Atorvastatin can be taken with or without food. Atorvastatin is usually taken once a day. Try to take your dose at the same time each day. Follow your doctor's instructions. Your doctor may want to monitor your liver function with blood tests before starting treatment with atorvastatin, at twelve weeks after both the start of your treatment and any increase in dose, and periodically (every 6 months) thereafter. Depending on the results of these tests, your doctor can determine how much monitoring you will require. Grapefruit and grapefruit juice may interact with atorvastatin. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Eat a low-fat, low-cholesterol diet. To realize beneficial effects from atorvastatin, avoid fatty, high-cholesterol foods. It is important to take atorvastatin regularly to get the most benefit. Do not stop taking atorvastatin without first talking to your doctor. Atorvastatin may need to be taken on a long-term basis for the treatment of high cholesterol. Your doctor may want you to have blood tests or other medical evaluations during treatment with atorvastatin to monitor progress and side effects. Store atorvastatin at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication. What happens if I overdose? Seek emergency medical attention if an overdose is suspected. The symptoms of an atorvastatin overdose are not known. What should I avoid while taking atorvastatin? Alcohol and atorvastatin can both be damaging to the liver. Alcohol should be used only in moderation. Discuss the use of alcohol with your doctor so that the potential for liver problems can be determined. Grapefruit and grapefruit juice may interact with atorvastatin. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

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